* item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Isaac's Tomb , Mom/Dad . Brimstone they called it raining down: the cities of the plain: Sodom, Gomorrah, Edom. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. ( : Telepathy for Dummies). Manage all your favorite fandoms in one place! However, If you also have flying you will always take damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, bomb, A random chance when you take damage to get an invincibility shield for 7 seconds, The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit, Converts all negative pills into their positive counterparts e.g. Even though they look like reskins of Cain, Isaac, Lilith, and the rest, most of them start with new items and abilities, effectively doubling the way you can begin a new run once they're unlocked. This works with all normal pickups, including cards, runes, chests and trinkets. After which, the only way to access an Angel Room is via the Sacrifice Room, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, brown, horns, When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, ?? For example rerolling Plan C (ID = 475) changes it into the Broken Glass Cannon, which is a hidden item with ID = 474, Items that are yet to be unlocked will also be skipped over, preventing you from getting items you don't have access to yet, UNLOCK: Unlock this item by defeating Delirium as Tainted Isaac, Upon taking damage you have a chance to drop the heart that you just lost. on enemy death, on room clear, on damage taken etc. *, blue, baby, grow, headless, golden chest pool, gold chest pool, Isaac's tears become coins and now have a 5% chance to drop pennies on the floor upon successfully hitting an enemy, Has a chance to drop when exploding a dead shopkeeper, A familiar blue fly that will follow Isaac's movement pattern but delayed by 1 second, Papa Fly will fire tears at nearby enemies that deal damage equal to Isaac's tear damage, A familiar baby that will follow your movement pattern on a 2 second delay, Tears that pass through the baby will double up and gain x1.33 speed boost, Isaac's normal bombs become pink and causes them to drop random pickups when they explode (e.g. Using the box again will put the picked up items back on the floor again, allowing you to move things between rooms, Can move any of the following: Batteries, Items, Trinkets, Hearts, Keys, Bombs, Coins, Chests and more, Using Moving Box with Car Battery will trigger 2 interactions at the same time: First it will drop all items currently inside the box and secondly will then pick up the current room's contents, When used in a room with 2 items you can choose from (e.g. devil deal, pink, brown, face, spots, Can be placed next to a pit and exploded to make a bridge, Can be placed over a broken red poop to overwrite it, causing it to no longer regenerate, * item room, treasure room, item room pool, starting, turd, brown, Drops a large bomb below the player which does 185 damage, Compatible with bomb modifiers, such as Glitter Bombs, Sticky Bombs etc, Has a chance to drop from the Wrath miniboss fight, REPENTANCE - Damage buffed from 110 to 185, Item Pool: Item Room, Wrath Miniboss, Bomb Beggar, * mr boom, boss rush pool, boss rush room, item room, treasure room, item room pool, bomb beggar, face, smile, grey, gray, Each tear is equal to your damage stat + 25 flat damage, The tears spawned from Tammy's Head retain tear effects of Isaac's tears, such as poison or homing, * golden chest pool, gold chest pool, dead, cat, white, yellow, tammys head, tammy head, When used, freezes all enemies in the current room for about 4 seconds, Item Pool: Item Room, Challenge Room, Mom's Chest, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Heart - 26.6% chance, Trinket - 6.6% chance. are now magnetically attracted to Isaac's tears, Can cause some enemies to have unpredictable movement, * item room, treasure room, item room pool, grey, gray, magnet, Tears are now charged up and fired rapidly in a burst of up to 5 shots at once, The amount of tears fired in the charge depends on how long you charge for, The eye has three states, white (not firing), black (first second of charging) and blinking between black and white. Most items that change tear color will also give Brimstone an exotic appearance, but they do not combine and only one color effect is shown. See its page for any differences to what is listed here. Harn 1.00 ms de dao y tendrn 5.25 ms de rango que las lgrimas normales disparadas por el ojo derecho. treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug, moms bottle of pills, Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time, The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time, * item room, treasure room, item room pool, green, snot, booger, ball, slime, Isaac's tears now split into two upon contact with enemies or the environment, Tears that split off from the main tear do less damage (tear damage * 0.5), Tears can keep splitting if they still have range and damage above 1, UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, * item room, treasure room, item room pool, pink, slug, bug, face, When used, replaces all pedestal items in the current room with another random item. There's Options, Double item room, Boss Rush) the Moving Box will pick only one of the items at random, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by HurleyFarrill, UNLOCK: Unlock this item by using Pandora's Box in the Dark Room floor, Your tears will now be connected together by beams of electricity which deals damage to enemies they hit, The lasers from this item deal 30% of your current damage stat, REPENTANCE - Technology Zero's lasers now deal 30% of the player's damage stat per tick (from 100%), UNLOCK: Unlock this item by having 2 technology items at once, *, black, white, grey, gray, round, circle, eye, key, hole, coin, slot, laser, Taking damage will spawn an orbital that rotates around Isaac, dealing contact damage to enemies and blocking enemy projectiles, A maximum of 3 Leprocy orbitals can be active at one time, Using the orbital to deal damage to enemies can cause it to break, Added as part of the Afterbirth+ Booster Pack #2. Clots returning back to Eve deal 3x damage as they suck back in, The type of heart consumed to create a clot will give it different abilities: Soul Hearts = More health, Black Hearts = Dark Matter effect, Eternal Hearts = Sacred Heart effect, Gold Hearts = Midas Touch effect, Bone Hearts = Compound Fracture effect, Rotten Hearts = Less health, Tainted Eve starts with this item, but can be used by any character after unlocking it and finding it in the item room, UNLOCK: This item comes along with Tainted Eve. Stat Down becomes Stat Up, 'Bad Trip' turns into 'Balls of Steel' and 'Amnesia' turns into 'I can see forever', * astrology, astronomy, item room, treasure room, item room pool, blue glow, m, Balances out your main stats to bring the high and low stats closer to an average value, All future stat upgrading items will now instead spread out across all other stats. . Chapters After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lilith, Item Pool: Item Room, Red Chest, Curse Room, During the transition between floors, this item shows you a preview of the item that will spawn in the item room, and the boss that will appear, This effect will work even if you have Curse of the Blind, but the item will still appear as a ? Multi-shot effects add 1 bomb to the barrage, up to 21 bombs. increased tears stat does not reduce the charge up time of Brimstone. 00:00. Chapters ?, Satan and The Lamb as Tainted Eden, Each brand new room, this trinket has a chance to transform into a copy of a random passive item, which gives you the effect for the duration of this room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eden, Gives a small chance to spawn a friendly Bony when clearing a room, which will throw bones at enemies until it takes enough damage to die, Can be either the regular white Bony or the black variant, UNLOCK: Unlock this trinket by defeating Isaac, ?? The laser deals damage equal to Isaac's damage and deals damage each tick. This is a one-time use of the Red Key item. Cannot be rerolled by 4-pip dice rooms and Spindown Dice, Clearing a room will spawn an extra reward, however only one can be picked up - the other one will disappear, UNLOCK: Unlock this item by defeating the The Beast as Isaac, Every half red heart you pick up gives a small but permanent stat increase, Randomly picks between +0.10 Damage Up, +0.05 Tears Up, +0.15 Range Up, +0.02 Speed Up, +0.1 Luck Up, +0.02 Shot Speed Up per half red heart, UNLOCK: Unlock this item by defeating The Beast as Magdalene, This item causes Devil deals to cost money instead of hearts, and shop items to cost hearts instead of money, Shop items cost heart containers, and pickups have spikes around them, The Devil deal conversion rate is 1 heart container to 15 coins, Devil deal items can be on discount similar to the shop, making it 1 heart container = 7 coins instead, UNLOCK: Unlock this item by defeating The Beast as Cain, Every time you enter a devil room and choose not to take an item, you get +1 Damage Up upon entering the next floor, The effect is shown via a cross above Isaac's head. The poison deals your tear damage per tick, for 2 ticks, Has no effect on Lilith, as she cannot fire tears, While firing tears constantly for 7.5 seconds, you spawn a poop cloud, which deals periodic damage to any enemies which come near it, The cloud deals damage equal to your base tear damage per tick, roughly 5 times per second, Clouds last 15 seconds before disappearing, The cloud can be pushed slightly by firing tears at it, Upon taking damage, Isaac starts to bleed, leaving a trail of blood and spraying blood tears everywhere which deal damage to nearby enemies, While bleeding, Isaac takes damage every 30 seconds, The blood sprays in the direction you are current firing, or just randomly near Isaac if not shooting your tears, The blood spray scales with your current tear damage and any future damage increases, This effect lasts until you pick up a red heart, Upon taking damage, this item gives a 25% chance to drop a full red heart, REPENTANCE - This entire item has been reworked, Enemy bullets have a 25% chance to be deflected back at the enemy, which will hurt them and apply the concussive status effect, causing it to be stunned for a few seconds, Every 20th tear fired will also fire a golden coin tear at the same time. This means you can leave rooms before defeating the enemies inside, Doesn't open locked doors, or the door that leads to the Boss Room, Heals one red heart container when picked up, This item causes nearby enemies to be affected by the charm effect, causing them to attack other nearby enemies, The charm effect will wear off very quicky when enemies move away from Isaac, This item causes your tears to become rocks, which have increased knockback and can break other rocks and objects. blue, white, triangle, Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral), Despite the increase in tear size, Dead Onion does NOT increase your damage stat. ipecac isaac seedhegelian theory of social change. Starts at +3.6 damage and goes to 0 after 30 seconds, While this temporary damage boost is active, each enemy you kill increases your damage slightly, allowing you to quickly kill multiple enemies and chain the effect for longer, This item also gives a -0.03 Speed Down for every food item held. Transformations Picking up Bone Hearts while at 12 hearts will remove charges from the Box, UNLOCK: Unlock this item by defeating The Lamb as Bethany, Spawns a ladder in the starting room of all future floors, which leads to an Angel Room, Angel rooms accessed by The Stairway are different - They sell angel room items and soul hearts for money, similar to the Shop, Pedestal items cost 15c, all other items (eternal/soul hearts, keys and holy cards) cost 5c. They do not block enemy shots, UNLOCK: Unlock this item by defeating The Beast as Tainted Lilith, Isaac builds rage each time you clear a new room. Rooms Trinkets ?, Satan and The Lamb as Tainted Magdalene, The first time you pick this trinket up, the heart container will be filled. white, grey, gray, A familiar that follows isaac around dropping white creep which slows down enemies that walk over it, Spawns 1-2 familiar blue spiders after every room, * item room, treasure room, item room pool, white, ball, dripping, A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight, Robo-Baby 2.0's lasers deal 3.5 damage per hit, UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy), * robo baby 2.0, item room, treasure room, item room pool, red, eyes, grey, gray, robot, A familiar which follows Isaac and spawns a blue flies as you're firing tears, Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, REPENTANCE - The Inner Eye now causes less of a decrease in rate of fire than previously, and now has a tighter spread. Smaller enemies spawn 2-3 tears, and bosses spawn a maximum of 16, Tears from this effect maintain tear modifiers and status effects that Isaac currently has, Isaac doesn't take damage from the tears created by this item, Every time you take damage, a tiny Isaac familiar will spawn, which follows you and shoots tears at nearby enemies that deal 1.3 Damage, The mini-Isaacs stay with you between floors, but can die if they take too much damage, Maximum number of mini-Isaacs is 16 at one time, Mini-Isaac's keep some of the abilities and appearance that Isaac has - e.g. ?, Soul of the Lost, 4 rooms: Rune of Ehwaz, Rune of Perthro, Black Rune, Soul of Isaac, Soul of Eve, Soul of Eden, Soul of the Forgotten, Soul of Jacob and Esau, 6 rooms: Rune of Dagaz, Soul of Samson, Soul of Azazel, Soul of Apollyon, Soul of Bethany, 12 rooms: Rune of Jera, Soul of Lilith, Soul of the Keeper, Tears have a chance to fire a fungus tear that sticks to enemies. Effects (D20 effect), 3 Dot - Rerolls all pickups on the entire floor, 4 Dot - Rerolls all pedestal items on the floor. While firing tears the water will be fired as a projectile across the room. This shield stacks with Holy Mantle, giving you 2 free hits, Added as part of the Afterbirth+ Booster Pack #5. Curses Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. Any subsequent hits give +0.4 Tears Up and will ignore the normal fire rate cap, Greatly decreases damage (x0.33 damage multiplier), Individual tears gain random worm effects (e.g. Rotten Meat = +1 flat damage, +1.5 range. Magdalene . Challenges The barrage size is 8 without any multi-shot effect. rocks, poop) in the room and deal 200 damage to all enemies in the current room, as well as every other room for the remainder of the floor, Also opens the boss rush door after Mom's Foot, blue womb door after Mom's Heart, secret rooms and super secret rooms, Like all single-use items, this item cannot be absorbed and used multiple times by the Void item, Entering a room with an angel statue will destroy it and automatically spawn one of the Angel mini bosses, REPENTANCE - This now blows up machines, beggars and fireplaces too, Upon use, this item will fart, pushing enemies away and causing a wave of rocks to spawn that spread outwards from Isaac in a circle, dealing 10 damage per hit to any enemies caught in it, Visually this item is very similar to Butter Bean, The rock waves can destroy destructible objects, e.g. Seeds yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. soul or black hearts, Your devil deal chance isn't ruined by this item taking away red hearts. This is shown by the Azazel skin spreading on Isaac's face, After 4 rooms, Isaac's face will flash red. if you have 99 coins it will create 3 x Quarters, 2 Dimes and 4 Pennies. This is one of the few, rare examples of a synergy granting a unique costume - another one being the costume granted by holding multiple copies of. achievement (collect 50 items in a single run), X-Lax - Spawns a pool of slippery brown creep beneath Isaac, Experimental Pill - Increases one random stat and decreases another random stat. Chapters Seeds Modes Attempting to fire the beam before it is fully charged will cancel the charge. Completion Marks Tear Appearance Items for 15c, hearts for 3c, sacks for 7c, UNLOCK: Unlock this card by defeating challenge #44 (Red Redemption), Activates a random effect from a Dice room, See the dice icon above for each possible effect, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Cain, All enemies in the current room are slowed and take double damage, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Samson, You turn into the Keeper, gaining triple shot, -0.1 Speed Down for 30 seconds, Enemies drop random coins while this effect is active, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Keeper, Activates the Book of the Dead effect, spawning a bone orbital or charmed Bony for each enemy killed in the current room, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Forgotten, When used, this card activates 5 random pill effects one after the other, UNLOCK: Unlock this card by defeating challenge #45 (DELETE THIS), Activates The Bible effect (granting flight) and gives a Seraphim familiar for 30 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Azazel, Spawns 6 clusters of rocks and objects that normally appear on this floor, Rocks have a pretty good chance to become tinted rocks, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Apollyon, Removes your oldest item and spawns 2 pedestal items from the current room's pool, Can remove either passive or active items, Doesn't remove your character's starting items, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Isaac, Teleports you to the ultra secret room on the floor, The ultra secret room is a red room containing an item from the angel room item pool. Summons Mom's foot which will stomp on a random enemy in the current room, dealing 300 damage, If no enemies are in the current room, the foot will target Isaac (and do damage if it hits), however it can be used to break rocks, Gives the player the Whore of Babylon effect for the current room, increasing damage and speed, Teleports the player to the Boss room on the current floor, *, the lost item pool, tarot, card, blue, red, If used in a Super Secret Room containing a Black Heart or Eternal Heart, it will spawn those types of hearts instead, Grants the same effect as 'My Little Unicorn', which makes Isaac invincible and deal 40 contact damage to enemies per hit, Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each, On or below the Womb, this acts as a random teleport, since there are no shops on those floors, Spawns a Slot Machine or a Fortune Machine, Gives the player the Magic Mushroom effect, which increasing size and all stats by 1 for the current room, If you use the Strength card with 12 heart containers, it will take you down to 11 when you leave the room, Gives the player the flying effect for the current room, allowing the player to fly over obstacles in the room, This card is useless if you have any item which allows you to permanently fly, * , the lost item pool, tarot, card, grey, gray, Deals 40 damage to all enemies in the room in a similar style to the Necronomicon, * , the lost item pool, tarot, card, red, blue, Gives the Book of Belial effect for the current room, increasing damage, Spawns some troll bombs at random locations in the current room, Each bomb deals 60 damage (normal bomb damage, On or below the Womb, this acts as a random teleport, since there are no item rooms on those floors, A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass), Killing a Devil Beggar, Key Master, or Shell Game Beggar gives you an increased chance of finding Angel rooms instead of Devil rooms. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. Explosions now only heal Isaac for half of a heart (previously healed a full heart), * item room, treasure room, item room pool, fire, heart, orange, burning, stannis, Makes tears break into 4 smaller tears on impact with anything, which deal half of your damage, * item room, treasure room, item room pool, brown, orange, headless, crickets body, When getting hit, this item has a chance to drop a soul heart or black heart, The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time, Enemies have a chance to drop half a red heart when killed, Item Pool: Item Room, Devil Room, Curse Room, Demon Beggar, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool devil pool, devil room pool, devil deal, item room, treasure room, item room pool, gimp mask, the lost item pool, grey, gray, black, An item only found in the secret room pool, * secret room pool, , the lost item pool, purple, black, grey, gray, flower, mtg magic the gathering, vintage, When you take damage, 1-2 coins will drop on the floor, When playing as the Keeper, this item drops 0-1 coins instead, * shop room pool, shop item pool, item room, treasure room, item room pool, pink, oink, Isaac's tears have a 15% chance of causing a fear effect, Feared enemies will run away from Isaac temporarily, The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Charge amount increases the barrage size; 2-4 knives at 0%, 8-10 knives 100%. Pressing 3 yellow buttons on the floor causes the minecart to be rideable. Magic Fingers ignores the +40 flat damage with Ipecac, removing the synergy between these two, * shop room pool, shop item pool, item room, treasure room, item room pool, tissue, Items The locust fly will do different things for each harbinger - e.g. Pressing it again allows you to throw it at enemies. Tears are fired in an arc. Transformations brown, brass, copper, dads key, dad key, * boss room pool, boss room item, item room, treasure room, item room pool, lumpy, red, balls, Using the portable slot takes a coin and has a chance to give a pickup - similar to how the normal slot machines work, REPENTANCE - The delay between uses was removed, allowing you to spam-use it, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, It will also sometimes randomly drop bombs. First, chemical signals cause the injured vessels to narrow to prevent more blood from leaking out. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. Azazel has a chance to fire a beam with the damage bonus. Secret Rooms, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lazarus, Every time you take damage, you drop up to 2 different types of consumables on the ground, Dropped consumables can be any variant of its kind - e.g. Isaac 's face, After 4 rooms, Isaac 's face will flash.... S damage and deals damage each tick with all normal pickups, including cards, runes chests... The room is n't ruined by this item taking away red hearts called it down. It again allows you to throw it at enemies obstacles in its path # 5 cancel! Added as part of the red Key item, 2 Dimes and 4 Pennies x27... Chemical signals cause the injured vessels to narrow to prevent more Blood from leaking.! 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